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Biostatistics
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What is the rationale for the scientific question asked?”

INSTRUCTIONS TO CANDIDATES
ANSWER ALL QUESTIONS

Introduction:  This section is expecting to answer, “What is the rationale for the scientific question asked?” The rationale needs to be based on a significant public health issue. Describe the relationships of interest and the purpose of the analysis.

Please conduct and a small literature search (1-3 papers) to understand the scientific question asked in the project and provide a brief summary in this section. You should also state your “research question” or “research objective” in this section. (this section should be brief and amount to a few paragraphs. Limit it to about 1 page double spaced.)

 

Methods: This section should outline your analysis (describe what steps and statistical methods you did to analyze the data and how you applied them to solve the questions asked.) You also need to provide a brief description of what statistical methods were used and the rationale or purpose for it. Please describe any statistical methods used for testing assumptions of the test if needed. If you created new variables for your analyses, you need provide the rationale for creating the variable and describe the method you used to create the new variable. Add a sentence referencing the software, in this case Stata, you used for all your analyses, just as you are expected to do for any peer review publication.

 

Results: The results section needs to mimic a peer review publication, so it needs to include the following elements:

 

Identify the variables used in the comparison and create a summary table that describes your sample. These descriptive statistics are based on the original data, rather than any new variables you create for your analyses.

 

Use the Table 1 Template in Appendix A to present your descriptive statistics.

 

For each set of variables select and compute the appropriate test statistic to assess the simple association between each independent variables and low versus normal birthweight infants. Describe the statistics you used in the Methods section and report the P value in the table.

 

Summarize you’re your findings based on the initial descriptive statistics in a brief paragraph.

 

You will be using multi-sample tests and/or multivariable models to address the primary question(s), so you need to provide analyses that confirm that the model assumptions are met.

 

Present your initial exploratory analyses on the original data that you used to make a preliminary assessment on the presence of potential outliers

and distributional characteristics relevant to the statistical model needed to address the primary hypotheses you are asked to evaluate.

Describe how you dealt with violations of the assumptions (selecting an appropriate transformation if applicable)

•    Fit the initial model with all the independent variables.

Provide detailed analysis of model fit based on residuals. At a minimum, you need to include a quantile normal plot to check the distribution of the residuals, residual versus fitted plot, residual versus each predictor plots, and studentized residual plots (to assess influence)

Describe the remedial steps you took to address issues identified in your analysis of the residuals

•    How you dealt with non-linearity.

How you dealt with observations that appear as potential outliers 

Fit the final model based on the remedial steps you took to resolve issues identified in your analysis of model fit.

Copy and Paste the regression results for your final model into your report and label it as Table 2.

Specify how the independent variables that appear in your final model were selected.

Summarize the key results from your final multivariable regression model in the text, and include a table with all the regression results in the body of the paper

Discussion: In this section you need to describe and interpret what the results mean in the context of the scientific question integrating all the questions asked for the project.

The bulk of your report should be the methods and the results. The discussion, like the introduction should be kept brief. It is okay to turn in reports less than the maximum, as long as everything requested is included and adequately covered.

Direct any questions about the project to your instructor or the TAs assigned to your class.

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