Questions:
1. What is the total number of units utilized/administered (how much was used) in each month for each
medication across all patients?
2. How many patients received Med A in each month from July to Nov? Med B?
3. What’s the average total monthly dose per patient for each medication in each month (July to Nov)?
4. In each month separately (September, October, and November) and also all together across these 3
months, how many patients are switched from Med A to Med B? In each month separately (Sept, Oct,
Nov), how many patients are started on Med B having not been on Med A before?
5. In each month separately (September, October, and November) and across all 3 months, for patients
switched to Med B, what is the average number of weeks the patients were on Med A before being
switched to Med B? (see time on medication definition below)
6. What is the average total monthly dose per patient per month (in patients that switched) of Medication
A before switching to Medication B (use time from question 5)? What is the average total monthly dose
per patient per month of Medication B (in patients that switched – assume Med B dose is for 1 month)?
7. If Medication A cost $1 for 100 units, what is the breakeven price point for Medication B (per unit of B)?
8. How much does the average total monthly dose per patient (Medication A and B) change for patients
switched September vs October vs November?
9. In patients that were switched to Med B, what percent of the 2nd Med B dose (total dose in month
following 1st dose) was the same as the 1st Med B dose? Higher than the 1st dose? Lower than the first
dose (but not a zero dose)? No dose at all (a zero dose)? (calculate for patients switched in September
only, October only, and Sept and Oct together, assume Med B dose is for 1 month only)
10. For patients that switch from Med A to Med B (question 4), what’s the average LAB B value for these
patients when they were on Med A? Med B?
11. Assume that more of medication A and B is generally associated with higher LAB B values. How does
your answer to question 9 and 10 impact the breakeven price point?
Background notes:
• XYZ client currently uses Medication A in all their patients and is considering a switch to Medication B. A
critical part of the evaluation of Medication B is how much of Medication B would be used in the XYZ
client’s patients. A trial of Medication B was conducted. The data in the excel file encompasses roughly
130 patients with data at least 2 months before switching medications and up to 3 months on the new
medication.
• Patients can be on medication A or medication B or neither medication, but not both medications at the
same time
• Medication B is given less frequently (~1/month) than Medication A
• The units of Medication A and Medication B are different and are not interchangeable or able to be
converted from one to another
• For time on medication, assume the patient is “on” Med A from the first recorded date of Med A
administration until the last recorded date of Med A administration
• Assume a week is 7 days and a month is 4.33 weeks
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