investigate the effect of salmeterol xinafoate on PEFR using a summary statistics analysis

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1. Summarise the data, including its structure. Use both numerical and graphical methods as appropriate. [7] 2. Investigate the effect of salmeterol xinafoate on PEFR using a summary statistics analysis. Check all model assumptions and interpret the results. [4] 3. Investigate the effect of salmeterol xinafoate on PEFR using a hierarchical regression model. Then re-fit the model and adjust for month and baseline PEFR. Check all model assumptions and interpret the results. Comment on how the results change in the adjusted model (with a focus on the intervention and variance estimates). [6] 4. Investigate the effect of salmeterol xinafoate on PEFR, adjusted for month and baseline PEFR, using an appropriate marginal model fitted using GEE. Interpret the results and compare them to the results for the corresponding hierarchical model. 

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