Assignment #4
Please formulate your answer in the space provided, and employing about the same size font. This assignment is open-book and should be delivered by email to me by noon, Nov Dec 2. The assignment covers sessions 1-26, with emphasis on sessions 20-26. The purpose of these assignments is to help you study and understand the material in a focused way. All questions have equal weight. The small space for answering questions is to help you formulate your own answers in your own words in a concise fashion, rather than pasting from the notes!! Actually, expressing the correct ideas succinctly is a very good sign of your understanding of what is important. I will try to assess, in the marking, whether I think you understand what you write in your answers.
These questions are a bit more challenging than in previous assignments. I am open to receiving questions pertinent to this assignment. If I decide to “help” anyone, I will give the same help to all by including the question and the “help” in a Q & A posting. Each question is worth 10 points, and there are 20 potential bonus points to encourage you to be imaginative and brave!
1 In session 20, an experiment is described (Figure 2) in which mice were generated by giving irradiated A strain mice bone-marrow stem cells from AxB mice, where A and B MHC antigens are different. The immune systems of these mice were allowed to regenerate over a period of 2 months. These mice were now grafted with skin from B strain mice, which was rejected in about 45 days. The researchers concluded that the skin of B mice was regarded as foreign and therefore the skin has antigens unique to it, not encountered by the AxB lymphocytes that developed in the irradiated A mice. Some immunologists are discussing this classic experiment over morning coffee. Some claim that to get this rejection the alleles coding for the “skin antigen” must be different in strain A and B strain mice, whereas other maintain this is not the case. Who is correct and why?
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